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In PepT1-knockout mice, KPV produced no anti-inflammatory or anti-tumorigenic effects, confirming that this transporter is not just a route of absorption it is essential to KPV's intestinal mechanism of action

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Similar promoter methylation events have been described in other cancers, including the extracellular regulation genes (WIF1), Dickkopf Wnt Signaling Pathway Inhibitor (DKK1-3), SFRP1, 2, 4, and 5) and intracellular regulatory genes (DACT1-3, Axin, APC)

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