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Since GAD is a cytosolic enzyme ( Figure 3 Metabolic pathways for degradation of glutamate and GABA While the primary event responsible for inactivation of the neurotransmitter action of glutamate and GABA is related to the high-affinity transporters for these amino acids, the subsequent intracellular metabolic pathways for degradation of glutamate and GABA are of functional significance [Ref

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