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108 indicated that the combination of exenatide and dapagliflozin decreased inflammatory markers linked to obesity, such as C-reactive protein and TNF-

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although long-term monotherapy with vitamin E reduced oxidative stress, SF was not reduced (50)

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121 Overall, these data accumulate to show that GLP-1 RAs provide not only metabolic and mitochondrial effects but also meaningful clinical impact for vascular and neuroendocrine protection that may ultimately decrease age-related decline in cardiovascular health, musculoskeletal health, and cognitive health