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A second intense period of discovery surrounded the mapping of the gene for MEN2 and the discovery that mutations of the RET proto-oncogene (12,13), a tyrosine kinase receptor (14), caused not only this genetic syndrome but also were found as somatic mutations in approximately 25% of sporadic MTCs (15)

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Gaudino, M

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Consequently, this model is well suited for evaluating the clinical efficacy of pharmacological interventions compared to some chronic or surgically induced OA models