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Studies have shown that trypsin induces the release of calcium ions from vascular endothelial cells, causing coronary artery-dependent vasodilation and reducing the contractile sensitivity of smooth muscle [79]

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Numbing cream is available, and the majority of patients stay comfortable throughout the session

Similarly, chemogenetic activation of PPG neurons led to reduced food intake and metabolic rate (Gaykema et al., 2017), and depletion of PVH GLP-1R resulted in increased food intake and obesity (Liu et al., 2017)