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A separate set of enzymes and transporters also plays a buffering role by eliminating acetyl-CoA from inside mitochondria created by the pyruvate dehydrogenase complex that is in excess of its utilization by the Krebs cycle

How GLP-1s can help reduce menopausal weight gain While HRT can help steady hormones and slow some of the physical changes that come with menopause, its not a magic fix for weight gain

Am J Med (2003) 115:4178