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All authors reviewed and revised the manuscript

The risk of hypoglycemia is increased when combined with insulin or insulin secretagogues such as sulfonylureas

Both are GLP-1-based medications that reduce appetite and support weight loss

That approach can make weight loss look successful on paper while setting up problems in real life

Even before GLP-1 reaches systemic circulation, this local portal GLP-1 signal produces strong effects on glucose uptake and insulin sensitivity in the liver and pancreas

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