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1,5-AG is one of the main polyol sugars in the human body, is mainly derived from food and is hardly synthesized by the human body (Yamanouchi and Akanuma, 1994)

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Available data indicate that SGLT2-i cause plasma renin activity (PRA) increase in the early phase of treatment, while PRA and aldosterone levels remain unchanged in chronic treated patients

This shift is what leads to the brightening effect many people experience