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Zweitens knnte sie das Verstndnis der Dosis-Wirkungs-Kurve schrfen, insbesondere ab welcher Dosis die Wirkung auf die Glukagon-Rezeptor-vermittelten Effekte (Energieumsatz, LDL-Reduktion) klinisch relevant wird

he asked me what the issue was or if I was having a problem

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Several observations suggest a possible action of GLP-1 on thirst-regulatory mechanisms, since GLP-1R mRNA has been located in brain areas related to the control of thirst, such as the preoptic area, glial cells lining the third ventricle and, especially, the neurons of the PVN, which is a key station for water balance regulation through the antidiuretic effects of vasopressin released by its projection to the neurohypophysis [44]

Their findings revealed a 30% reduction in MACE compared to monotherapy

Clin J Am Soc Nephrol (2017) 12(8):136673