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doi.org/10.1016/j.molmet.2019.09.010 Jastreboff, A

No MTD was determined

Bowel patterns normalize

Type 2 diabetes coverage is common

For most patients, these changes improve heart health

157 Although it is generally assumed that AT 2 receptors oppose the responses mediated by AT 1 receptors, and therefore may attenuate the pressor effects of Ang II, a possible role of AT 2 receptors in the regulation of renal hemodynamics and sodium homeostasis remains to be unclear