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Some other experimental studies have given another explanation for the improved carbohydrate metabolism, that LCA supplementation can reduce the ratio of acetyl-CoA to free CoA in the mitochondria, thereby stimulating the activity of pyruvate dehydrogenase (PDH) (Calvani et al., 2000)

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Tirzepatide administered via subcutaneous injection requires precise needle selection to balance delivery accuracy with patient comfort

All authors read the manuscript and approved the final version of the article to be published

Obesity pharmacotherapy is a rapidly moving field and further research on long-term clinical efficacy, safety and cost-effectiveness will inform better their place in the treatment algorithms for obesity and obesity-related complications over the next years