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10.1038/nchembio.2239 Nat

2009;5:e1000602

These trials revealed the modulation of leukemic gene expression and disease stabilization in some patients, 429,430,431,432 although neurotoxicity and limited monotherapy efficacy emphasized the need for rational combination therapy and stratification

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Cost-effectiveness analysis favors TB-500 for patients seeking broad systemic benefits, despite higher upfront costs