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7 days) significantly accelerates the outgrowth of tendon fibroblasts from Sprague-Dawley rat Achilles tendon explants [1]

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In a study by Rotondo Dottore, G., it was mentioned that H2O2 has a dual effect on fibroblast cell proliferation, with low concentrations of H2O2 inducing proliferation and releasing cytokines, while high concentrations of H2O2 are cytotoxic, when cell viability decreases (9, 31)

doi: 10.3389/fphys.2025.1651151 Received 20 June 2025 Revised 17 October 2025 Accepted 23 October 2025 Published 16 December 2025 Volume 16 - 2025 Edited by Geoffrey A

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