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Sulforaphane supplementation has been shown to increase hepatic and blood glutathione levels in human studies (Fahey et al., Proc Natl Acad Sci, 1997

Gastric mucosal protection by agents altering gastric mucosal sulfhydryls

CYP2E1 variants affect NAPQI production rates

A glutathione deficiency can lead to hypothyroidism

Overall, we conclude that PC patients with low expression of VRK2 are sensitive to GSH-targeting therapy, while PC patients with high expression of VRK2 are re-sensitive to GSH-targeting therapy following VRK2 inhibition, indicating genetic aberrance of VRK2 expression stratifies the response of PC to metabolism-targeted therapies