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The consequences of these modifications are that IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor, has very low affinity for the insulin-like growth factor-binding proteins (IGFBPs), and has improved metabolic stability resulting in approximately three times greater potency than IGF-1, with a significantly longer half-life of about 2030 hours relative to IGF-1s half-life of about 1215 hours
Combination therapies can be more effective as they target multiple pathways involved in glucose regulation, potentially offering better glycemic control and additional benefits like weight loss
Read more here: nature.com/articles/s4143 #Ophthalmology With #GLP-1 receptor agonists like semaglutide rising in use for diabetes & obesity, concerns are surfacing about possible ocular side effectsespecially NAION, a serious optic neuropathy
Anawalt BD, Merriam GR 2001
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