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It is important to note that there are some important differences between steroidal and nonsteroidal MRAs, which have been described in the review by Agarwal and colleges, published in 2021 [65]
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To put that into more concrete terms: on the 0 to 18 CDR-SB scale, lecanemab, a monoclonal antibody thats not approved on the NHS (because of cost) but is approved by the FDA, showed a 0.45-point advantage at 18 months, which is about 27% slower than placebo
Future investigations should implement standardized exercise prescriptions, longer follow-up, and preregistered multicenter designs to ensure methodological consistency and improve translational relevance
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