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Obesity induced alterations in redox homeostasis and oxidative stress are present from an early age

In an iron overload model in L6 skeletal muscle cells, these cells respond to the perturbation by attempting to activate autophagy to maintain optimal homeostasis and functionality

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Additionally, lactate metabolism enhances cellular NADPH availability through a glucose-sparing mechanism: When cells use lactate as their primary fuel source, glucose is redirected towards the PPP, which generates NADPH essential for fatty acid biosynthesis (28)