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Cardiovascular benefits: Beyond their glucose-lowering effects, some GLP-1 agonists have demonstrated cardiovascular benefits in clinical trials, including a reduction in the risk of major cardiovascular events like heart attacks and strokes

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But because the biology of a multi-hit disease phenotype involving aging, diet, hemodynamic stress, inflammation, and organ-organ crosstalk does not reduce to a set of differential equations

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This is where the answer becomes more nuanced

Bupropion handles the dopaminergic, reward-driven eating patterns that tirzepatide may not fully address