This enhanced glycolysis results in high lactate and low glucose concentrations in inflamed joints, 581 disrupting immune cell balance
(4) Mechanistic complexity : The polypharmacological nature of TCM necessitates integrative multi-omics approaches, including metabolomics, network pharmacology, proteomics, immunomics, and gut metagenomics, to decode its regulatory effects on NLRP3 inflammasome
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Pyridoxal phosphate (PLP) is integral to one-carbon metabolism, a series of biochemical reactions necessary for the synthesis of nucleotides and other molecules essential for DNA and RNA production (6, 18, 57, 58)
[iii] Bowers, C
Biochemistry 30 , 613619 (1991)