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doi:10.18632/oncotarget.11168 [2] Cangul IT, Gul NY, Topal A, Yilmaz R

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It may integrate signaling between osteoblasts and osteoclasts via the receptor activator of nuclear factor kappa- (RANK)/receptor activator of nuclear factor kappa- ligand (RANKL)/osteoprotegerin (OPG) pathway, thereby influencing the balance of bone remodeling [131, 141]

It is naturally produced in human gastric juice, but is also found in small amounts in the gastric juice of other mammals

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