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These symptoms stem from how these medications slow gastric emptying to promote satiety and weight loss

Oxygen consumption was measured in the basal state, after treatment with oligomycin (2 mg-L-1), a Complex V inhibitor used to determine the relative coupling of respiration and phosphorylation, and FCCP (5 ), a ionophore and mitochondrial uncoupling agent used to determine maximal respiratory capacity of the cells

The direct reaction estimates the conjugated bilirubin fraction, and with the addition of a promoter (alcohol), the indirect reaction measures the unconjugated fraction

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This dose produces meaningful weight loss for many people, though some will eventually need higher doses for optimal results