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However, an analysis of other secondary endpoints showed that treatment with lixisenatide led to a lower risk of developing new-onset massive albuminuria in patients with T2DM, slowed the progression of diabetic nephropathy in patients with massive albuminuria-associated T2DM, and demonstrated a positive impact on maintaining body weight (Pfeffer et al., 2015)
Accordingly, our models predicted a strong induction of several metabolic pathways in non-infected cells of COVID-19 patients based on an increased number of reactions active in the respective context-specific metabolic models, which was even more pronounced in patients with severe disease (Fig
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