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Moreover, disruptions in glutathione metabolism have been linked to diseases of the central nervous system, frailty, sarcopenia, infections, chronic liver conditions, metabolic disorders, and pulmonary and cardiovascular diseases (3)

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Mechanistic studies of the plant GCL demonstrated that reversible disulfide bond formation alters catalytic activity with the oxidized protein more active than the reduced protein (Jez et al., Subsequent crystallographic and functional studies established the molecular basis for this thiol-based redox-switch