glp-1 and muscle mass loss receptor agonists, which are effective for weight loss, can cause substantial loss. A Comment in @TheLancetEndo discusses the effects of GLP-1 receptor agonists on skeletal muscle mass: https://t.co/qQ85u86B1G 1/2) New research suggests GLP-1

GROMADA J, HOLST J J, RORSMAN P.Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1 [J]

How they work Oral GLP-1 drops Oral GLP-1 drops may be small-molecule GLP-1 analog formulations or compounded liquid forms designed for buccal or sublingual absorption

Nature 546 , 118123 (2017)

Additionally, the effects of combined therapy appear to differ between major cardiovascular events and heart failure-related outcomes

Released rapidly in response to nutrient ingestion, especially carbohydrates and fats, it enhances insulin secretion from pancreatic beta cells in a glucose-dependent manner, effectively lowering postprandial blood glucose without risking hypoglycemia

Individual ingredients like prebiotic fiber and berberine have evidence for modest metabolic benefits , fiber supports gut health and satiety, berberine can reduce fasting blood sugar , but the magnitude of effect is far smaller than pharmaceutical GLP-1 receptor agonists