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Testing for these genetic predispositions before starting therapy allows your provider to match you with the medication most likely to work best for your unique biology

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This gradual escalation approach is broadly consistent with titration strategies used for other GLP-1-based therapies already authorised in the UK, such as semaglutide (Wegovy) and tirzepatide (Mounjaro), both of which are subject to NICE technology appraisal guidance and NHS prescribing frameworks

Phosphorylation of ATF4 and S6K1 results in purine and pyrimidine biosynthesis, respectively