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doi: 10.1016/s2213-8587(19)30160-3 21 LvZMWangQWanQLinJGHuMSLiuYXet al

10.1038/nature09146

Mechanisms of Estrogen carcinogenesis: The role of E2/E1-quinone metabolites suggests new approaches to preventive interventiona review

Recent research has shown that hyperglycemia induced cellular stress, such as ERS (120) and oxidative stress (119), which stimulate the pyroptotic process in renal cells, and various signaling pathways, such as TLRs/NF-B/NLRP3 inflammasome signalling pathway, TXNIP/NLRP3 inflammasome pathway, ATP/P2X purinergic signalling pathway, and MAPKs/NLRP3 inflammasome signalling pathway (119, 121)

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