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These findings emphasize that targeted antagonism of NMDA receptor signalling lowers body weight independently of MC4R, indicating that this preclinical drug candidate might not only be effective in treating polygenic obesity but also holds potential as an effective weight loss strategy for patients with loss-of-function mutations in MC4R , the most common form of monogenic obesity 32

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ClinicalTrials.gov ID: NCT05013229

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Among females, RBC folate demonstrated suppression effects contributing 57%, 55%, 68%, 47%, 34%, 58%, 58%, 63%, and 42% of the total associations between PFOS and LDL-C, PFOS and TC, PFOS and TG, PFOS and AIP, PFOA and TG, PFNA and TG, total PFAS and LDL-C, total PFAS and TC, and total PFAS and AIP, respectively (Figure S12, Table S7)