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Cagrilintide had one of the lowest GI odds ratios among incretin-class compounds in a 2025 network meta-analysis, but combination GI burden has not been formally quantified

Dysregulation of GHIGF-1 axis can amplify the synergistic effect of GH and IGF-1 to promote uncontrolled cell proliferation, cell movement, angiogenesis, and suppress apoptosis to increase risk of neoplasia (272)

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Aberrant histone modifications may upregulate oncogenes or reduce the expression of tumor suppressor genes