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These data demonstrate that CaMKK2 is a component of a signalling hub that enables crosstalk between kinase and small G-protein signalling networks that regulate brain function

In hypoxic pulmonary hypertension (HPH), elevated CUL5 expression binds TRAF6 (TNF receptor-associated factor 6), activating the NF-B pathway to stabilize HIF-1, thereby increasing VEGF expression and driving pulmonary vascular remodeling and HPH progression (39)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 222.Sadowska A.M