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Cardiovascular outcomes Semaglutide has a major advantage here, not because its cardiovascular effects are necessarily superior, but because they have actually been measured in a dedicated outcomes trial

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Among epigenetic mechanisms, histone methylation has garnered particular attention for its role in shaping chromatin structure and regulating transcription of key profibrotic genes such as transforming growth factor-beta 1 (TGF-1) and type I collagen (131, 132)