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It effectively eliminates stubborn hyperpigmentation and prevents the formation of spots and acne scars by inhibiting melanin production

It is endogenously biosynthesised in the liver and kidneys from lysine and methionine through a four-step pathway proceeding via trimethyllysine and gamma-butyrobetaine, the final hydroxylation being catalysed by gamma-butyrobetaine dioxygenase

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Before imputation, variants were filtered by call rate 5% missingness

Medications to reduce the frequency and severity of hypoglycemia may be required for cases unresponsive to dietary modification

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