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The high dose was titrated to that dose after a week at a dose of 5 mg/160 mg

After announcing the state would initiate coverage of GLP-1s to combat obesity in September 2022 as part of their state employee health plan, the state reversed course and in January 2025 announced it was opting to end that coverage beginning July 1, 2025

Evidence-based treatments like therapy, SSRIs, or other appropriate medications are safer and more effective

10.1016/j.bcmd.2017.09.002 32

Evidence supporting this relationship comes from studies on mice treated with antibiotics, which demonstrate that the disruption of gut microbiota leads to increased GLP-1 levels in circulation along with decreased locomotor activity [123,124]

No published clinical trials have tested GLP-1 microdosing specifically in MS patients