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Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice

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1170 HK, the enzyme that initiates glycolysis through glucose phosphorylation, is competitively inhibited by 2-deoxyglucose (2-DG), which structurally resembles glucose and binds to HK2, thereby hindering its activity through the accumulation of phosphorylated 2-DG