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Notably, this U-shaped curve was observed irrespective of plasma vitamin B-12 concentrations
In SURMOUNT-1, nausea occurred in 24.6% of participants on 5mg, 33.3% on 10mg, and 31.0% on 15mg
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A 12-week trial showed that subjects receiving 1 mg per day of AOD 9604 lost an average of 2.6 kilograms compared to 0.8 kilograms in the placebo group
This not only validates the gut resistome and microbiota results for the enrichment of the family of Enterobacteriaceae , but implies that many of the members of this family harbor multiple ABR genes, potentially on plasmids, and thereby impart multidrug resistance
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