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Sensory Circumventricular Organs, Neuroendocrine Control, and Metabolic Regulation

A large study of 2000 patients without diabetes showed that using Ozempic/Wegovy in addition to diet and exercise for 68 weeks led to a 15% weight loss (1/3 of the participants lost up to 20% of their starting weight.) Those in the control group that were only coached on the lifestyle changes lost 2.4% of their weight

In summary, the authors said

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What clinical circumstances make GLP-1 receptor agonists better than metformin for managing Type 2 diabetes, and how do these circumstances influence patient outcomes