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Vitamin B 12 deficiency, like folate deficiency, may lead to decreased synthesis of methionine and S-adenosylmethionine (SAM), thereby adversely affecting methylation reactions
[13] Pernicious anemia is the most common cause of clinically evident vitamin B 12 deficiency worldwide
a form of vitamin B12 that may not actually active in humans (6, 7)
Dosing Calculation Examples If you reconstituted a 5 mg vial with 2 mL bacteriostatic water , your concentration is 2,500 mcg/mL: For 250 mcg dose: Draw 0.10 mL (10 units on insulin syringe) For 300 mcg dose: Draw 0.12 mL (12 units on insulin syringe) For 500 mcg dose: Draw 0.20 mL (20 units on insulin syringe) AOD-9604 Administration Guide Proper subcutaneous injection technique ensures optimal absorption, minimizes discomfort, and reduces risk of injection site reactions
Start: 300 mcg daily for Weeks 14