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Chemical modification of metformin into sulfenamides and sulfonamides has also improved the cellular accumulation of these compounds in cancer cells, with a subsequent increase in their cytotoxic efficacy

10.1007/s00213-006-0313-7 146

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The difference is how many metabolic pathways each medication activates

doi: 10.15252/embj.2020106230 70 RaneJ

Pharmacokinetics, pharmacodynamics and safety of single, oral doses of GSK1278863, a novel HIF-prolyl hydroxylase inhibitor, in healthy Japanese and Caucasian subjects