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Mercken EM, Crosby SD, Dudley W, Jebailey L, Krzysik-Walker S, Villareal DT et al

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The dominance of follistatin in cancer cachexia reflects the central role of activin-A (alongside myostatin) in cachexia biology activin-A drives SMAD2/3-dependent muscle wasting independently of myostatin, and follistatin-344 neutralises both ligands simultaneously