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Lipid profile improvements (TRIUMPH-4): Non-HDL cholesterol: Clinically meaningful reduction Triglycerides: Significant reduction hsCRP (inflammatory marker): Significant reduction HDL cholesterol: Not significantly improved (consistent with Phase 2 findings) The triglyceride reduction is particularly notable and likely related to glucagon receptor activation, which enhances fat oxidation
Nauck M, Frid A, Hermansen K, et al, for LEAD-2 Metformin Study Group
Semaglutide in adults with type 1 diabetes and obesity
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How Tirzepatide Fits Into the Comparison Tirzepatide helps explain why receptor targets matter, but receptor count alone does not rank medicines