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Though these drugs are generally less effective than newer alternatives, they can work for many people: Orlistat (Alli, Xenical) reduces the amount of fat absorbed by the intestines

Time window and exit rules: a sufficient treatment window (36 months) should be reserved to achieve clinically meaningful weight loss (typically threshold of 5%10%) alongside IR improvement

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The marketing aimed specifically at women, particularly around perimenopause and hormonal weight gain, is a targeting strategy rather than a pharmacological distinction

While GLP-1 therapies can be highly effective, they are most successful when paired with healthy lifestyle changes