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Effectiveness was measured by the proportion of patients achieving weight loss targets of 5%, 10%, 15%, and 20%, using efficacy data from the STEP-8 head-to-head trial, a 68-week, randomized, double-blind study conducted in the USA, comparing semaglutide 2.4 mg versus liraglutide 3 mg in adults who were overweight or had obesity without diabetes

In contrast, the PLA group started with a lower glucose level, peaked to match the GRS group towards the end of the exercise, but then dipped to a lower level again

Tirzepatide is also modified with a C20 fatty diacid side chain, which helps it bind albumin and extends its half-life to about 5 days

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