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Bariatric surgery often leads to a 60% to 70% reduction in excess body weight, while GLP-1 medications like semaglutide typically result in a 15-20% total body weight loss

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A well-known example is the JAK2 V617F mutation, common in polycythemia vera (PV) and related diseases

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Overall, six in ten adults (61%), including similar shares across age groups, say they think Medicare should cover the cost of these drugs when prescribed for weight loss for people who are overweight, a share that rises to about seven in ten (71%) among those who have ever taken these drugs

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Microdosing is an alternative that involves taking a prescribed low dose

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