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Monogenic IBD typically manifests as very early onset(very early onset inflammatory bowel disease (VEO-IBD)), caused by rare pathogenic variants in genes such as IL10R and X-linked inhibitor of apoptosis protein (XIAP) [193]

[DOI] [PubMed] [Google Scholar] 32.Ma L, Ju P, Wang W, et al

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The calibration curves revealed that the predicted probabilities were generally consistent with the observed probabilities, indicating that the model had good goodness-of-fit (HosmerLemeshow test: p = 0.095) ( Figure 4A )

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Significant progress typically appears by 12 weeks