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doi: 10.1016/j.tcb.2022.02.009 50 ZhuJBerisaMSchworerSQinWCrossJRThompsonCB

doi: 10.1016/j.advnut.2022.10.002 129

10.3390/IJERPH20010552 12

In a study where juvenile rats were treated orally with clonidine hydrochloride from day 21 of age to adulthood, a slight delay in onset of preputial separation (delayed sexual maturation) was seen in males treated with 300 mcg/kg/day, which is approximately 3 times the MRHD of 0.4 mg/day on a mg/m 2basis