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Energy stress activates LKB1-dependent AMPK, which phosphorylates downstream TSC2, then promotes the formation of the TSC1/TSC2 complex, and further inhibits the activity of mTORC1 [30]

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It also supports positive ageing, particularly for brain and eye health

In addition to GLS inhibition, the role of oncogenes and tumor suppressors in regulating glutamine metabolism makes it a promising venture for therapeutic strategies

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Long-term treatment with recombinant human pentraxin 2 protein in patients with idiopathic pulmonary fibrosis: An open-label extension study