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The question is no longer whether combining these therapies is biologically plausible

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Dimethyl fumarate decreases the levels of GSH and GPX4 and increases the expression of 5-lipoxygenase in GC B-cell diffuse large B-cell lymphoma, which helps induce ferroptosis by impeding nuclear factor-B (NF-B) and JAK/STAT signaling pathway (115)

These two findings together explain why clinicians continue to worry about product integrity above all else

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