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A review of 38 RCTs comprising 7,551 patients on ICI therapy evaluated the incidence of endocrine irAEs and found a higher incidence of hypo and hyperthyroidism, especially in patients receiving combined ICI therapy (OR: 3.81

On the other hand, vitamin injections can cause localized side effects such as pain and redness at the injection site, as well as mild diarrhea and itching

Peptide injections are bioactive amino acid chains administered subcutaneously or intradermally to stimulate specific cellular pathways

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Starting with 10mg vials for the first 8 weeks and transitioning to 20mg or 30mg vials for the maintenance phase is the most cost-effective and practical approach for most research protocols