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Mutant KRAS induces the monocyte to become the tumor-promoting phenotype (M2 type) through secreting many factors to elicit polarization in macrophages (Song et al., 2016)

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[53] In the other three trials (NCT3987919, NCT03882970, and NCT03730662), participants were randomly assigned to receive either tirzepatide or another antidiabetic medication, and both the patient and the provider knew which medication was being given