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The Authors reported that treatment with incretins significantly suppressed the FSH-induced synthesis of progesterone through the inhibition of the expression of progestogenic factors and enzymes, whereas there was no significant effect on oestrogen synthesis by rat granulosa cells, thus suggesting the possible role of GLP-1 RA in the treatment of dysregulated steroidogenesis in PCOS [43]
The severity and duration of these adjustment symptoms vary considerably between individuals, influenced by factors such as your baseline metabolic health, the specific GLP-1 medication prescribed, your starting dose, and even your stress levels during the initial period
2024;44:NP809NP818
PLOS ONE
If taking oral semaglutide, take it at a completely different time (some clinicians recommend evening dosing for one or the other)
There are always pros and cons to treatment
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