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Progressive loss of -cell identity and insulin resistance is generally associated with type 2 diabetes

First, PKA phosphorylates CREB, which simultaneously promotes anti-inflammatory IL-10 transcription and directly inhibits NF-B nuclear translocation, reducing TNF-, IL-6, and IL-1 production

The result is thinner, shorter hair that falls out more frequently

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Without strict environmental food controls, individuals with PWS rapidly develop severe obesity, which increases risks for type 2 diabetes, sleep apnea, heart disease, and early mortality